NOW HIRING 10 New Job Openings In Wilmington

first_imgWILMINGTON, MA — Below are some of the newest job openings in Wilmington:Full-Time Special Education Teacher (Pathways Program) at Shawsheen Elementary SchoolFull-Time Educational Assistant (Stepping Stones Program) at Shawsheen Elementary SchoolFull-Time LPN/Educational Assistant at Wilmington Middle SchoolFull-Time Middle School Science/Bible Teacher at Abundant LifePart-Time K-8 Physical Education Teacher at Abundant LifePart-Time Extended Day Director at Abundant LifePart-Time Extended Day Assistant at Abundant LifeFull-Time Service Advisor at Bill Dube HyundaiFull-Time Pressroom Feeder at Kirkwood PrintingFull-Time Solar Service Technician at Vivint Solar(NOTE: Wilmington businesses — Feel free to send me your job postings at wilmingtonapple@gmail.com.)Like Wilmington Apple on Facebook. Follow Wilmington Apple on Twitter. Follow Wilmington Apple on Instagram. Subscribe to Wilmington Apple’s daily email newsletter HERE. Got a comment, question, photo, press release, or news tip? Email wilmingtonapple@gmail.com.Share this:TwitterFacebookLike this:Like Loading… RelatedNOW HIRING: 10 New Job Openings In WilmingtonIn “Business”NOW HIRING: Wilmington Public Schools Posts 5 New Job OpeningsIn “Education”NOW HIRING: 60 New Job Openings In Wilmington (Week of August 4, 2019)In “Business”last_img read more

Three Reasons Apples iCloud Isnt Ready for Business

first_img Enroll Now for Free Free Workshop | August 28: Get Better Engagement and Build Trust With Customers Now 1. iCloud is personal, not professional. It is overwhelmingly geared toward individual users with more than one Apple device. The problem is that the same service used to sync music and television shows is also used to share calendars and documents between devices. Differentiating professional data, contacts, calendars and documents from personal ones, while possible, can require more time and effort than some entrepreneurs are willing to put in. Related: Steve Jobs: Victim of His Own Dogged Determination? 2. Collaboration is limited or doesn’t work.Apple’s iCloud is device-dependent. Group-sharing options — for instance, syncing calendars among co-workers — are limited, and when they are present they’re restricted to other iCloud users. Not only does this require your colleagues to own an Apple device, they also must be using a compatible operating system and have an iCloud account set up.The iCloud also lacks document sharing capability. For limited document storage — say you need to access a document on the road from your iPhone — it can work, but the document has to be stored in your personal iCloud. Again, the iCloud is a solo experience.Related: How Apple’s Siri Could Destroy Local SEO 3. Other business sharing solutions do it better.To some, it might seem as though Apple is trying to reinvent the wheel when it comes to business file sharing. Other team-based document sharing solutions such as San Mateo, Calif.-based Sugar Sync or Google Apps can usually be easier to set up and more flexible.The mobile version of Google Apps — which can be accessed on an iPhone, iPad or even an iPod Touch — is fast, stable, device-agnostic and allows for first-rate team access. All it takes is to bookmark your Google Apps account homepage in your iPhone or click on the Apps button in the Google iPhone app to create a superior solution to the iCloud.Given its limited scope and that there are so many other ways to access files from the Web, why bother with iCloud? Our bet is that most businesses won’t.Related: Why Entrepreneurs Love Steve Jobs Have you tried or do you use Apple’s iCloud? Tell us about your experience in the comments section below. While Apple may be a gem in the eyes of its customers, one of its newest features — the iCloud — is sorely lacking when it comes to applications for small-business users.Apple markets iCloud, its cloud-computing and file-syncing service, as a powerful content storage solution. But businesses can struggle to get serious productivity out of iCloud. And as an enticement for businesses looking to switch over to Apple products, iCloud doesn’t begin to make the sale.Here are three reasons you might want to skip the Apple iCloud for your business: min readcenter_img Opinions expressed by Entrepreneur contributors are their own. This hands-on workshop will give you the tools to authentically connect with an increasingly skeptical online audience. February 6, 2012last_img read more

Today we have the great pleasure to introduce you

first_imgToday we have the great pleasure to introduce you to James Turk, a well-known investment guru, international investor, and co-founder of the increasingly popular GoldMoney.com.In this interview, James will talk about:His past and the lessons of relevance to all those who want to live an international life.Current trends and what people can do to protect themselves during these volatile times.His GoldMoney service, one which we receive quite a few questions about here at International Man every month.So, without further ado, let’s begin…International Man: For those who aren’t familiar with you or your work, can you tell us a bit about yourself?James Turk: I have over 40 years of experience in international banking, finance and investments. I began my career with Chase Manhattan Bank, now JPMorgan Chase, which is one of the big New York banks. I then worked with one of the world’s top commodity traders, before moving to Abu Dhabi where I managed the commodity department for its sovereign wealth fund. It was one of the seven countries in which I have lived, but I now live in Europe.I have written extensively over the last 25 years about money and investments. Many of my articles are posted on the Internet, but I am particularly proud of a book I co-authored with my friend, John Rubino, The Collapse of the Dollar and How to Profit from It. It was first published in 2004 and correctly laid out the reason for owning gold and why banks and other financial companies like Fannie Mae were heading for trouble. We also explained why the bubble then prevailing in the housing market was ready to burst.In the late 1990s I formed GoldMoney with my oldest son, Geoffrey, who is now its CEO. Since its launch in 2001 GoldMoney has become a leading provider for buying gold, silver, platinum and palladium online to buyers worldwide. It is presently storing in vaults in London, Zurich and Hong Kong over US$2.2 billion of precious metals owned by customers located in more than 100 countries.Lastly, I am also a director of the GoldMoney Foundation, a not-for-profit educational organization dedicated to providing information on the role of gold and silver as money and currency and their importance to society. I am a firm believer that gold’s use as money is inextricably interlinked with human liberty. The Foundation promulgates this key point through published material, videos and conferences.IM: When did you personally start living and investing overseas?JT: I always wanted to live abroad and travel, which is one reason I joined Chase. They promised an overseas assignment when I completed my training program in New York City, and in 1971 I moved to Thailand. I spent most of that decade living and working in Asia. It was a great experience and provided a strong base on which to build my business career.It was the early 1970s when I first began international investing for my personal portfolio. I don’t remember the year, but I remember the event well. I tried to invest in a fund managed by Robeco, a big Dutch asset management company. They didn’t accept my application because I used my US address, and the fund was not registered with the SEC.That irritated me, being self-reliant and believing that I did not need any government agency watching over my shoulder when I made an investment. It also made clear to me the nanny-state environment in which we lived back then, which in my view has become even more onerous and oppressive today. But that event from 40 years ago had a useful outcome. It set me on a path to learn the ins-and-outs of international investing and the arcane rules governments imposed.IM: What motivated you to look outside your home country for fortune and opportunity in the first place?JT: Though I was born and raised in the States, I had an international perspective as long as I can remember, probably because my father was born in Europe. As Shakespeare so wisely advised, the “world is your oyster”. In this regard, I have always believed that you can do or achieve anything you want in life. It just takes planning and a lot of hard work.Everyone has the freedom to do so, but not everyone has the same motivations. Nor does everyone have the goal to view the whole world as an opportunity to improve their situation in life and to make sure their children have a better standard of living than they did as children. This objective was important to my parents. So maybe I learned it from them, but then again, maybe it is just human nature because I have seen that motivation time and again in many countries and many different cultures.IM: What steps have you taken personally to plant flags overseas?JT: There are many. I live in Europe and have travelled to over 50 countries. The company I founded is European-based, but has a global customer base. My wife and youngest son are British. I could go on, but those are the ones that immediately come to mind.IM: In a previous conversation, it was mentioned to me that Doug Casey’s book, The International Man, was an important influence on your way of thinking. Can you elaborate on that?JT: Yes, it was one of the sources of good information that I read back in the 1970s. There was not a lot of material back then on how to internationalize your life, which was my objective. So I bought a copy and learned a lot from it. There are two ways to gain useful experience – “reading” and “doing”. Both are invaluable.TrendsIM: In a recent article, you mention the “Last Plane Account“, which basically suggested setting up structures overseas so that if all domestic assets were seized, one would have a nest-egg available to still live a comfortable life. When did you first realize such a plan was needed for US citizens?JT: The name “last plane account” was an informal one that we used in Chase to refer to a marketing program that explained the necessity for southeast Asian businessmen to have bank deposits outside their home countries. The idea was that if turmoil wracked the country where you lived, you and your family could get on the “last plane” and live somewhere else in the same manner to which you were accustomed, even if you needed to leave behind many assets – like a house and your company’s factory.Remember, the domino theory still prevailed back in the 1970s, and everyone wondered and worried about what country in that part of the world would be the next to fall to communism. If it did, you clearly would want some of your wealth invested globally so that you and your family could live comfortably if forced to flee your home country, or just because you simply chose to do so. The idea was that you could then return to your home country once a sane political climate was restored with a rule of law that protected property rights.At first I didn’t realize that everyone needs a “last plane account” – even Americans. But my thinking began to change not long after moving to Thailand. I became friends with a wealthy Thai businessman whose family lost a fortune in real estate when the Chinese Red Army under Mao took control of that country. They left China only with their suitcases, which fortunately for them carried some gold and jade. After fleeing China, they settled in Thailand and through hard work re-built their fortune with the capital they were able to bring with them. It was actually a story that I eventually heard many times over the years I was in Asia.Then in late 1974, I agreed to move to Beirut, Lebanon, which back then was a plum assignment in the bank. However, the civil war there began before I could pack my bags, and because I had a family, the assignment was cancelled with mutual consent. It was a wake-up call for me. Like the experience related to me by my Chinese friend, it opened my eyes, and I began to really recognize that there are a lot of unsafe places in the world. More to the point, over the years I’ve seen dozens of countries change from good to bad, while some changed from bad to good.Sometimes the change occurs rapidly, as it did in Lebanon. Sometimes the change occurs slowly, which is what happens in most countries. The change can be so slow as to be imperceptible to most people living there, which is one of the reasons I recommend that people live for a time in different countries. It gives you a different perspective.When I look at the States, Thailand and the other countries where I have lived, from outside, I see things that I missed when I lived there. I think this perspective is important to understand that we live in a world that is constantly changing. So regardless of which country you were born, I recommend that everyone travel and live abroad, at least for a time, to gain some useful and unique experiences. When you do, I think you will better understand the reasons for a “last plane account” and appreciate the need to prepare for an uncertain future.IM: Can you tell us what such an account would consist of?JT: Clearly, I would not recommend today what we at Chase were offering back then, namely, bank deposits. These do not make sense in today’s topsy-turvy world.I would put into the account the same thing that you would put in any portfolio. There would be undervalued assets as well as safe assets in a mix that would enable you to sleep well at night knowing you were prepared to live comfortably somewhere in the world if you left your home country.The safe assets would of course be gold and a home for shelter. The undervalued assets would primarily be stocks, particularly a globally diversified portfolio and one that paid reasonable dividends to provide income. I don’t recommend commercial real estate, but other real estate – like an apartment building, farmland or timberland – could also be a safe asset in the right jurisdiction.Remember though, there is a fundamental difference between visible wealth and wealth that cannot easily be seen. Visible wealth is always a potential target for governments around the world looking for assets to tax or even confiscate, and one must factor in that risk. In fact, this risk is one of the reasons for diversifying globally. Diversification always mitigates risk.IM: With all this money printing in the world do you see hyperinflation in the US dollar and hence the world?JT: Sadly, yes, I do expect hyperinflation, and we are getting very close. Hyperinflation manifests itself in two ways, depending on the nature of the currency. In Weimar Germany in the 1920s and Zimbabwe more recently, very few people had bank accounts. Nearly all commerce was conducted with cash-currency. In contrast, in Argentina in 1991 nearly everyone had a bank account, with the result that nearly all commerce was conducted with deposit-currency. In other words, payment for goods and services was conducted through the banking system with checks, wire transfers, plastic cards and the like. All three countries experienced hyperinflation, which always has the same cause, regardless how it manifests itself. It boils down to a simple chain of events.A government spends too much, forcing it to borrow. Because governments have difficulties cutting back on spending when they have unlimited access to their central bank and no external discipline or constraints imposed on politicians’ aspirations to spend, eventually these borrowings become bigger than the market has the capacity or willingness to lend. The central bank then steps in to create the currency the government wants to spend, whether it is running a printing press in Zimbabwe or the computer in Argentina.Both examples are generally referred to as “printing money”, but now it is usually called “quantitative easing”. Maybe governments think that by giving it a name change, the process somehow becomes acceptable. Call it what you will, but it is the same thing and if not stopped, inevitably leads to hyperinflation. Given that the president and Congress don’t seem willing to change direction, and given their plans for more spending and more deficits, the US dollar is clearly on the path toward hyperinflation.IM: If so, what will the end of the US Dollar look like for the man on the street?JT: It will look like the Continental, America’s first currency, or the currencies of dozens of other countries that followed the same path. The dollar will be worth nothing. This outcome is particularly tragic because we failed to learn from the framers of the American Constitution. One of the reasons they aimed to create “a more perfect Union” was because of the economic hardships and dislocations caused by the collapse of the Continental. They purposefully created with the Constitution a common market and common currency. Their intent was made clear by one of the first acts of the new Congress, The Coinage Act, which George Washington signed into law in 1792. It was the law of the land until being ignored in the 20th century by politicians wanting to expand the scope of the federal government. To achieve that aim, they needed to spend money. But they could not do that with the dollar being tied to gold and silver.Precious metals cannot be created “out of thin air”, so they provide the necessary discipline on government spending. The US, and indeed, the entire world has abandoned that discipline and money is now created capriciously by central bankers.IM: For those who have followed the gold and silver commentaries for the last number of years, they will already know that you are exceptionally bullish on precious metals right now. However, in your mind, could something happen where the trend towards higher prices stalls for a while or potentially even reverses?JT: I assume you are asking about a major price reversal, and not just some temporary setback. In my view, only one thing would cause that. There would have to be a massive reduction in the quantity of dollars, and I don’t see any prospect for that. The Federal Reserve doesn’t seem intent on doing that given it has said it is committed to preventing deflation.Of course, at any moment in time the price of gold or silver can have a setback. That is the nature of bull markets. But don’t let these periodic corrections shake you out of the market. The key to successful investing is to accumulate assets when they are undervalued, and continue to hold them through periodic corrections. Only sell them when they become overvalued. It sounds easy, but can be hard to do in practice because people often get emotionally attached to assets, be it a house, a stock or gold.To eliminate the emotion, I always rely upon objective measures of value. Two that I use most frequently for gold and often write about are my Fear Index and my Gold Money Index. Both of these indicate that gold remains undervalued. But aside from these objective measures, I think there is also a good anecdotal one. I expect all fiat currencies to collapse. Consequently, you will not sell your gold when it becomes overvalued; you will spend it. In other words, gold will once again become currency, which is one of the goals we are working toward at GoldMoney. At that future time when gold becomes overvalued, you will take the gold you are now accumulating and spend it to invest in assets that are undervalued or spend it buying consumer goods. We are still far away from that moment.IM: What are your thoughts on possible confiscation from government or forced buy back of gold from its citizens, and is there some safety by owning precious metals with a service like GoldMoney?JT: The future of course cannot be predicted, but we nevertheless know that respect for private property is declining in many parts of the world. In the 20th century gold was confiscated by Lenin in Russia, Hitler in Germany, Mussolini in Italy and Franklin Roosevelt in the US. So don’t assume that confiscations can’t happen in the 21st century. I always say to prepare for the worst, while hoping for the best. In this way you will still get by, even if by an unfortunate turn of events the worst possible outcome happens.Because the future is unknowable, it is impossible to determine the perfect strategy to take advantage of future events. The best we can do is to protect ourselves from wealth destroying future events, like confiscation. I believe the best way to do that is through diversification. In other words, don’t put all your eggs in one basket, and GoldMoney can be helpful in diversifying your precious metals.When you buy physical gold and silver – and I only recommend physical metal, not any of the paper products purporting to offer physical metal – there are only two ways to do it. Buy it and store it yourself, or buy it and have someone store it for you, which is what GoldMoney offers.Each alternative has advantages and disadvantages. If you store gold yourself, you have it at hand, but run the risk of theft. Also, if you need to sell, it can be a bother to take your coins or bars to a dealer, who may then require them to be refined, which adds cost.With GoldMoney, you do not have your gold at hand, but it is stored for you in specialized vaults in London, Zurich and/or Hong Kong at your choice and is insured. You also have nearly instant liquidity. You can easily sell your metal back to GoldMoney. The proceeds are immediately wired to your bank account, which, depending on the time zone in which you live, may mean you receive the proceeds the same day. It is also convenient because all transactions are done online 24/7.GoldMoney BasicsInternational Man: You’ve referenced it a few times already, but, for those of our readers not yet familiar with GoldMoney.com, can you give us a really brief overview? James Turk: GoldMoney allows customers in 105 different countries to buy gold, silver, platinum and palladium online, and store these metals at secure vaults in London, Zurich and Hong Kong. Customers can conduct transactions in nine major currencies and also take physical delivery of their gold in the form of 100 gram and 1kg gold bars. Our governance procedures and regular audits provide assurances of integrity to our customers that their precious metals are being stored safely with us. IM: What prompted you to start GoldMoney in the first place? JT: The idea for GoldMoney came to me in 1979. I had been reading extensively, including many great works like Howard Buffett’s brilliant 1948 speech and dozens of books on money, particularly those of Ludwig von Mises and the Austrian school of economics. I re-read Atlas Shrugged and some of Ayn Rand’s other works. Another influential book from back then that comes to mind is The Market for Liberty. From these and other works I began to understand the importance of re-establishing gold’s role as currency. It was clear to me that human liberty and gold were inextricably interlinked because gold money controls government spending. When this spending has limits, so do government depredations. I wanted to live in a world where property rights were respected and the rule of law was followed, and naturally assumed other people shared that same aim, which meant that my idea for creating a technologically advanced gold money offered a profit opportunity. Of course the technology to make my vision possible was not available back then, nor did I think the technology would become available in my lifetime. Fortunately, the rapid advances in communications and computers over the next twenty years eventually made GoldMoney possible. My son and I formed GoldMoney in the late 1990s, which we launched in early 2001. I have not lost sight of my original vision and the important outcome that can be achieved by enabling gold to circulate once again as currency. IM: What makes GoldMoney different from some of the other options out there? JT: Buying allocated physical bullion, as facilitated by GoldMoney, guarantees you hold and own the metal in your name. Our stringent governance procedures and regular audits provide our customers with assurances that their metals are safe and that they are the undisputed owners. The freedom and ease of accessing the global precious metals markets online, 24 hours a day, and the variety of metals, storage facilities and accepted currencies offer a high level of comfort and diversification. This makes GoldMoney a uniquely secure and convenient precious metals provider. IM: Can you briefly take us through the process of signing up for an account? JT: People with residency in the US, Canada and 42 other countries are eligible for fast tracking – meaning they can sign up for what we call a Basic Holding quickly and easily online by clicking on the “Free Sign Up” button on our website GoldMoney.com. The entire process takes only a few minutes and customers can start funding their Holding in order to purchase metals immediately. Customers can upgrade to a Full Holding free of charge at any time. IM: In your mind, what is the single greatest reason someone signs up for a GoldMoney account – for speculating on the price of the metal, for savings, as a way to internationalize, something else? JT: People may of course have different reasons for opening a Holding. But I always say that precious metals should be thought of as your savings rather than as something that you “invest” in or speculate on. After all, an ounce of gold today is exactly the same as an ounce of gold 50 years ago. Like a quart, ton or meter, it is a consistent measuring stick. What changes is the value of currency in relation to that ounce of gold. Over time, the purchasing power of gold is preserved – in contrast to fiat currencies, where your purchasing power declines. More and more people are realizing this, and come to the conclusion that it makes sense to hold gold and other precious metals rather than national currencies, particularly now because one hardly earns any interest income with today’s artificially low interest rates. As precious metals regain mass acceptance as a medium of exchange and store of value, those who have been steadily accumulating them will recognise the benefits.Gold Money ChallengesIM: What are the challenges with running a company like GoldMoney? JT: There are of course many, just like there are in any company. But as we face and overcome these challenges, we always have one objective in mind, which is to serve our customers’ best interests. One of the many things I learned from Von Mises is that the “Customer is King”, which is a guiding principle always foremost in our minds and actions. In short, companies are built by serving their customers’ best interests efficiently and continuously. IM: Over the past year, I’ve heard some of the announcements that GoldMoney has had to suspend or even shut down operations in various jurisdictions such as the Netherlands. Is this something you feel can be rectified so that you can enter such markets again? If so, how? JT: This is unique to the Netherlands, owing to the unusual burdens placed on us by the Dutch regulators, the Netherlands Authority for the Financial Markets (AFM). The AFM has the view that precious metals are included within the concept of “investment objects” which are to be regulated by the AFM. We are of the opinion that Netherlands’ regulation is not applicable to GoldMoney because we operate in Jersey, British Channel Islands, rather than within the Netherlands – but we have been unsuccessful in changing the AFM’s view. As we do not want to subject ourselves, and by extension our customers, to unnecessary and unpredictable regulatory requirements, we reached the difficult conclusion that the only way to resolve this situation was to cease all business with individuals resident in the Netherlands. We do have every intention of accepting business from Dutch residents again in the future should the regulatory environment there change. IM: I have an associate who has a GoldMoney account and his wife has another. For a while, he would regularly transfer goldgrams to her without issue. As of the beginning of the year, that particular function has been suspended. Can you tell us why that happened and whether that particular benefit of your service will be implemented again? JT: Our decision to turn off the facility to transfer metals between GoldMoney customers in all countries except Jersey is based on lack of customer demand and increasing regulatory burdens. It is our intention to offer this service again in the future, which will depend on customer feedback and regulatory changes. IM: If a company like GoldMoney can’t use gold as money because of legislative and regulatory burdens, what does this say about any other competing currency? JT: Governments today seem to think that they should enjoy monopoly control of money and currency, even though both are products of the market just like any other good or service. Consequently, all free-market currencies will have a difficult time in gaining a foothold against national currencies. But because national currencies are losing purchasing power rapidly, it is inevitable that gold will once again return to its traditional and rightful role at the center of global commerce. After all, gold has been money for 5000 years, and it still preserves purchasing power better than any national currency, which for 40 years now have been backed by nothing. But the growing financial and monetary problems today make clear that this 40-year experiment with fiat currency is going badly. This result is inevitable, as proven by the dozens of other attempts throughout history to make fiat currency work through central planning and control. Eventually gold returns to center stage as the dominant money and currency in global commerce, and I suspect that this time will be no different given that the future of fiat currency is looking increasingly doubtful.Protecting GoldMoney ClientsIM: What safeguards has GoldMoney established to ensure that the person who buys physical metal is protected if the business happens to fail? Would they lose their assets? JT: Although this is an extreme unlikely scenario, customers will receive their physical metal in any of the gold, silver, platinum and palladium bars we offer, provided they have a balance greater than one bar. This includes the London Good Delivery Bars, as well as the 100 gram and 1 kilogram gold bars. Alternatively, customers can receive the equivalent value of their metals in one of the 9 national currencies we offer. A court appointed liquidator would complete this winding-up process. IM: How does GoldMoney ensure that the goldgram amount is actually in the client’s account? Couldn’t it all be just a game of numbers? JT: The quantity of metals allocated to customers’ Holdings that is recorded in GoldMoney’s database is equal to the amount of metal that is being stored in the vaults at all times. This one-to-one ratio is always maintained and forms a key part of our governance model. 100% customer ownership is assured by top-quality independent third-party reports and audits from the vault operators, Inspectorate – a commodity testing and inspection firm – and by regular audits by a big-4 accounting firm. GoldMoney is simply a guardian of its customers’ assets. IM: When someone buys metal from GoldMoney, are they officially an owner of their holdings or simply another creditor to the company itself? JT: Customers who own precious metals with GoldMoney own it in the form of allocated physical metal. This means that they are direct owners of their metals, and that GoldMoney does not have any claim on its customers’ assets. Customers’ metals do not appear on GoldMoney’s balance sheet, meaning that our customers do not have any counterparty risk.Common QuestionsInternational Man: What are some of the more common reasons people say they don’t want to use GoldMoney? James Turk: Some people prefer to have their gold and silver in their hands. They want to be able to touch and feel it. Given all that’s gone in the financial world over the last few years, and with the MF Global debacle still fresh in people’s minds, this is understandable. But there are real risks to storing large quantities of metal at home. It is therefore natural that people would look to store their metal in other ways and other countries, and this is where GoldMoney can help. GoldMoney’s governance and audit procedures are rigorous and stringent and the Certificates & Reports are available for review on our website. With regards to storing metals at home or some other private location, GoldMoney can help customers by supplying physical metal, as we deliver 100-gram and 1-kilo gold bars produced by Baird & Co. of London to our customers’ home address. The main risk of storing metals at home is burglary, and liquidity and geographical diversification are limited. IM: What would you say to someone who would be a bit nervous buying “paper” / “promise to pay” gold through GoldMoney? JT: GoldMoney does not sell any “paper gold“. It only sells physical metal, which is always what I recommend owning. “Paper gold” offers exposure to the gold price, but that is all. The buyer does not own gold, but rather a claim to gold. Futures, options, ETFs and gold certificates are examples of paper-gold products, and they all have counterparty risk. None of these items give you the guaranteed 100% ownership of allocated gold that you have when transacting with GoldMoney. Because all customers’ metals within GoldMoney are stored in vaults, and because we deal exclusively in the physical bullion markets with a variety of dealers, there will always be bidders for customers who wish to sell, and sellers for those customers eager to buy. Bringing supply and demand into equilibrium is what the price discovery process is all about. Therefore, GoldMoney will always be able to honor your sell or buy order in a prompt manner.Logistical QuestionsIM: What are the options available to customers for taking delivery of their gold? JT: Customers can take physical delivery of their gold at any time in the form of 100 gram and 1 kilogram bars. These bars, which have a purity of 99.99%, are refined by Baird & Co. Ltd. in London and shipped to our customers’ home address by insured mail. The customer places the delivery order online through their Holding, and we will automatically process it. We can also arrange the delivery of 400oz Good Delivery Bars. If you wish to diversify your metals and move your metal balance in your Holding partly or entirely for storage in a different country, you also have the option to do that when logged into your Holding. IM: Where are the holdings stored? JT: Customers can store their gold and silver at VIA MAT vaults in London, Zurich and Hong Kong. You can also store gold and silver at a G4S vault in Hong Kong. Platinum is stored by VIA MAT in Zurich and Hong Kong, and the same company also stores palladium in Hong Kong. IM: Which are the most popular of these companies to store holdings? JT: The largest holdings are at VIA MATs gold and silver vaults in London and Zurich.MiscellaneousIM: Do you have any merchants that currently allow you to purchase items with GoldMoney? JT: Currently there are no merchants that accept GoldMoney because we have turned-off the payment capability to customers in all countries except Jersey, where we are based. IM: What is currently the breakdown among your client base in terms of allocations between gold, silver, platinum and palladium? What metal the most popular? JT: With the launch of GoldMoney in 2001 we offered gold only and introduced silver in 2006. Platinum followed in 2009 and Palladium in January 2011. Given gold’s long established bona fides as money, you probably won’t be surprised to learn that most of our customers’ metals in terms of US dollars are held in gold. However, silver is a close second to gold in terms of total USD value. Platinum and palladium holdings with us are smaller, though the popularity of these metals is likely to grow. The amount of metals and currencies held on behalf of our customers are disclosed in the monthly report on our website. IM: What is the average size of account in GoldMoney? JT: It has been growing since inception, and is presently $103,000. However, the median account size is only about $10,000. There is no minimum or maximum amount you can purchase and hold, so we have a wide range of customers from small to large. IM: For those who want to find out more, what’s the best way? JT: Our website www.goldmoney.com offers detailed information about our services and governance procedures. We also have a Research section that provides background information on the precious metal markets. The Frequently Asked Questions section offers guidance for new and prospective customers and our customer support team is always happy to answer any questions – by phone, email or through our secure internal message system. IM: Sir, it was a pleasure. Thank you.JT: Thank you for the opportunity to speak with you as well.[To interact with other international men and women all around the world, consider joining the International Man Network. It’s completely free to join, plus you’ll have access to a private forum of thousands of like-minded individuals who are sharing their “boots on the ground” tactics and experience on how to internationalize one’s life and wealth. Sign up here.]About the Author: Inspired by the work of best-selling author and renowned speculator Doug Casey, International Man is a global network of freedom-seekers, investors, adventurers, speculators and expatriates looking to live an international lifestyle – be it asset, income, personal diversification or any combination of the three. Learn more at www.internationalman.com.last_img read more

In This Issue BLS reports 171000 new jobs Bi

first_imgIn This Issue.*BLS reports 171,000 new jobs. *Bias to buy dollars intensifies. *RBA to announce a rate cut this afternoon. *Euro falls though 200-Day moving avg.And, Now, Today’s Pfennig For Your Thoughts!Who Is The BLS Attempting To Fool?Good day.  And a Marvelous Monday to you! The last day before the Big Election Day here in the U.S. I hope you all enjoyed the Big Boss, Frank Trotter’s, analysis of the election, in the Sunday Pfennig & Pfriends. On top of all the other things that Frank does better than most people, he also writes! He will be able to fall back on that when he retires one day. And he’ll be better than anyone else doing it at that time!Now, you may think I’m just trying to build up some brownie points with the Big Boss. But I’ve told him this to his face for years now, and have invited him to participate in the Pfennig, whenever he feels like it. Besides, at my age, I’ve learned that those brownie points don’t really matter when the rubber meets the road!OK. On Friday, I told you that the bias to buy dollars was strong, and that traders were pricing in a disappointing Jobs Jamboree. However, a funny thing happened on the way to the forum. Instead of a disappointing Jobs number for October, the number was questionable once again. Yes, I’ll just throw that out there, and get it on the discussion board, Front & Center this morning.  Oh! And traders changed horses in the middle of the stream, and decided that the number of jobs created was worth switching their reason to buy dollars.So. The Bureau of Labor Statistic (BLS) said that the economy added 171,000 jobs in October.  Here’s what questionable. of the 171,000, 90,000 were added by the BLS for the birth/ death adjustment.  Now, why do I say that 90,000 jobs added out of thin air, is questionable?  Well, long time readers know that the Birth / Death Model, tries to account for new businesses that open up and aren’t online with reporting jobs yet. (they also are supposed to subtract for businesses that close). And just last week I reported to you that CEO’s had reported that they were laying off and firing large numbers of workers. So, if little old me came across that story, they had to have at least “heard about it” at the BLS, right?  So, then, why would they add 90,000 jobs knowing all too well that more jobs are being lost right now?So, here’s how my mind works.  171,000 minus 90,000 and you get 81,000, which is much closer to the 111,000 I called for on Friday, and. would be considered disappointing, right?  And then to just muddy up the picture even more. The BLS tells us 171,000 jobs were added but the Unemployment Rate increased to 7.9% from 7.8%…  (remember last month, the BLS said we added 114,000 jobs and the unemployment rate fell from 8.1% to 7.8%?)  is your mind spinning around and performing carnival tricks in an attempt to make sense of this Unemployment Rate? Mine is. and that’s why I say the BLS just throws a dart at numbers on the wall to get the rate!OK. if only I could hold to my thought from a month ago that I was not going to let any economic data report that printed before the election carry any weight. Unfortunately, the markets were all over this BLS Jobs data like a cheap suit. So. since I write about the markets, I have to spend time on this. I don’t buy the number. You can’t make me! HA!So. like I said above, currency and metals traders decided to change horses in the middle of the stream, and switched back to the trading pattern that rewards the dollar for strong U.S. economic data.   I think that the overnight markets that were gone for the weekend when the Jobs number printed on Friday, saw this data last night when they returned to their desks, they laughed. The chuckled and probably fell out of their chairs. But, then, they pulled themselves back up, and decided to keep the bias to buy dollars in place.Then in the morning sessions of Europe, the traders there kept the bias to buy dollars in place. The euro has really taken it on the chin in the past week. And there really hasn’t been any news from the Eurozone to make the euro lose 2-cents in the past week. Greece’s Gov’t will present a new austerity package to the Greek Parliament today, with a vote announcement expected on Wednesday. I look for this new package to pass. Look, Greece really has no choice, except to drop out of the euro and default.  So, the Greeks might not like being told that these austerity measures are coming, but there’s not much they can do about, except burn down the library.Tonight, the Reserve Bank of Australia (RBA) will meet. and even though I’ve been telling you how the aggressive calls to cut rates in 2013, have been getting pared back, that doesn’t change what the markets had already priced in. and that is one final cut for 2012. And I believe we’ll see that tonight. The markets are probably thinking the rate cut will come in December, as they are marking up the Aussie dollar (A$) (one of the few currencies in the black this morning) this morning. But. I believe it will come this afternoon. so look for that. but remember, this cut is already priced in. so the actual pain to the A$ will be muted. at least that’s my opinion, and I could be wrong.Well. I really don’t believe that much that happens today and tomorrow, data wise, is going to garner much attention, as all eyes are on the U.S. election tomorrow. I was watching some football yesterday, and the announcers for the Washington Redskins and Carolina Panthers game, said that since 1940, the outcome of the Redskins’ game prior to the election had been the indicator of who wins 17 of 18 times. So. if the Redskins won, the incumbent won, if the Redskins lost the challenger won. Well. if that means anything to you. the Redskins lost yesterday.Funny little indicators always intrigue me, I have no idea why. I guess it plays well with my loving a good conspiracy theory!  I just know that I’ll be so happy to not see election ads on the TV going forward.So, I already told you about the RBA meeting tonight, but that’s not all for this week! We’ll also see the Central banks of the Eurozone (ECB) and the U.K. (BOE) meet this week. I really don’t believe the ECB will have any rabbits up their sleeve, but the BOE could very well, add to their current total of Quantitative Easing (QE).  The outcomes for the euro and the pound sterling won’t be driven by the Central Bank meetings this week though.  But there’s always that “chance”, eh?I’ve watched the price of Gold go from down $1 to up $2.75 this morning, not much movement, not like the further taking down of the shiny metal last week. Did you see the story that appeared late last week that Gold is in short supply in Nepal, and that bullion traders had stopped sales of Gold bars and coins due to a failure by the commercial banks to deliver supply.  Hmmm. and price of Gold fell?  Supply & demand.  What don’t the price manipulators understand?  This is a crying shame that this gets to continue on and on and on, like the Energizer Bunny.The price of Gold is still above the 200-day moving avg, so the shiny metal has that going for it! But, you have to wonder if the price manipulators (PM’s) have the goal of taking down the price of Gold below that 200-day moving avg?  Hey! If you’re not going to get your wrists slapped for doing the deed, then you just continue doing the deed, eh? You betcha!  And like I’ve said before the PM’s would get their due if we could muster up enough demand for physical Gold & Silver. It’s got to be physical, not ETF’s. Folks, those ETF’s are not Physical Gold. and you can’t get physical Gold out of them!The euro fell below its 200-day moving avg overnight (1.2830) to trade in the 1.27 handle.  It’s not been a good year for the euro, as it spent the first 8 months of the year below the moving avg, and then things looked brighter, and the last two months it traded above the moving avg.  This move lower could be the beginning of another period of euro weakness folks. I would watch carefully for that. for this is what normally happens when a currency recovers, and then can’t add to that recovery, it eventually goes for a ride on the slippery slope.Then There Was This. I have a good friend that goes back to my days at Mark Twain Bank. her name is Ellie, and she has an excellent mind for investments (and other things!) she has written a couple of books on investing through the years.. Well, when Ellie sees something that makes a lot of sense, she sends it to me.. As so it was on Saturday, when I received an email from Ellie.  It was my friend John Mauldin’s outside the box article. Here’s a snippet from investment analyst guru, Charles Gave. “So the solution to our current malaise is very simple: We have to stop now. Reduce government spending, stop manipulating money, let market pricing return – or the result will be a vicious cycle of low growth and rising debt, or certain depression.The choice is just as simple for investors: Stick with countries that have avoided the worst of the bad policies, like Canada, Sweden, Denmark, Poland, Switzerland, Australia, New Zealand, Singapore, Hong Kong or even Korea. All of these countries either kept fiscal balances and taxes low (or started reducing them), and/or regulated their financial systems to prevent casino madness.Consider certain countries that are improving on the margin. This includes the UK. It also includes China, which is opening its capital account and liberalizing its financial system. “Chuck again. Thanks to Ellie for sending this to me, and thanks to Charles Gave for his thoughts on what needs to happen here in the U.S. and then some choices as alternatives should the U.S. continue down this vicious cycle.To recap. The bias to dollars that existed Friday, was given a boost as the Jobs Jamboree as reported by the BLS showed a rise of 171,000 jobs in October. I say hogwash! But it is what it is.  The RBA meets tonight, and Chuck expects to see a rate cut tonight. The BOE and ECB also meet this week, with only more QE to be announced by the BOE. Greece presented a new austerity package to the Parliament for a vote Wednesday. And Gold gets taken down again.Currencies today 11/5/12. American Style: A$ $1.0360, kiwi .8240, C$ $1.0035, euro 1.2780, sterling 1.5980, Swiss $1.0590, . European Style: rand 8.7365, krone 5.7495, SEK 6.7060, forint 221.05, zloty 3.2265, koruna 19.7405, RUB 31.70, yen 80.25, sing 1.2255, HKD 7.75, INR 54.60, China 6.2447, pesos 13.06, BRL 2.0335, Dollar Index 80.83, Oil $84.87, 10-year 1.69%, Silver $31.07, and Gold. $1,682.40That’s it for today. Happy Birthday Rachel! Ugly steel gray days with raw temperatures, are back for us all to enjoy (NOT!) Typical November. My poor Missouri Tigers outplayed Florida throughout their game last Saturday, but managed to lose it anyway. UGH! Next up is Tennessee this week. Still no hockey. I got out my Blues baseball cap in hopes it will be good luck for a settlement!  Fat chance, eh?  Well. time to go. last day before the election. Like I said I’ll be glad to see it over with! Hopefully we won’t having any hanging chads or any other nonsense with voting fraud. I hope you have a Marvelous Monday!Chuck Butler President EverBank World Markets 1-800-926-4922 www.everbank.comlast_img read more

Fed Chair Says this is Americas 1 Threat leaked

first_img Fed Chair Says this is America’s #1 Threat [leaked in CA mtg] Imagine the secrets Fed chairwoman Janet Yellen is privy to: thwarted bank runs, interest rate spikes… the truth behind major swings in gold prices. So when she confessed America’s #1 risk at a private meeting in California, it’s no surprise word leaked out. She says this event could lead us into a “devastating spiral.” We at Casey Research believe it has already started. Click here for the full story. Recommended Links – — Companies are hiding more from you than you realize… Back in the late 90s, energy company Enron was a Wall Street darling. From 1998 to 2000, its stock surged 342%. It became America’s seventh biggest corporation…but the company was a farce. Management used shady accounting to inflate its sales and profits. When the fraud came to light, Enron’s stock plummeted. In 2001, it filed for bankruptcy. • In April, former Enron CEO Andy Fastow issued a serious warning… Fastow was one of the main actors in the Enron scandal. He spent six years in jail for his crimes. According to Fastow, many corporate executives are now doing what he did at Enron. He even accused tech giant Apple (AAPL) of misleading investors. Business Insider reported: His point – an entirely correct one – is that the world’s largest company today is engaged in tax dodging behavior that, while perhaps technically legal, is clearly designed to increase profits and inflate the stock by misleading and confusing regulators (and perhaps investors) via a massively complex web of entities – exactly what he did at Enron! And this is 100% routine, common behavior among most large US companies. Some people might find Fastow’s claim ridiculous. He is a convicted felon, after all. But Casey readers know better than to trust Corporate America. • Regulators have accused Valeant (VRX) and SunEdison (SUNE) of similar crimes… You’ve probably heard about the drug maker Valeant and the renewable energy company SunEdison. Their downfalls have been two of the year’s biggest investing stories. Like Enron, both companies were hot investments. From January 2013 to July 2015, Valeant gained 332%. SunEdison’s stock surged 892% over the same period. Like Enron, both companies used “creative accounting.” According to The Wall Street Journal, the Securities and Exchange Commission (SEC) is investigating whether “SunEdison misrepresented its cash position to investors as its stock collapsed.” Valeant is under investigation for its pricing and accounting practices. And like Enron, both stocks have crashed. SunEdison plunged 99% before it announced plans to file bankruptcy. Valeant’s stock has plummeted 89%. • The mainstream media paints Valeant and SunEdison as a couple “bad apples”… According to most reports, it’s rare for public companies to pull tricks on investors. But if you’ve been reading the Dispatch, you know that’s not true. For the past few months, we’ve been telling you about the huge surge in share buybacks. A share buyback is when a company buys its own stock from shareholders. Buybacks reduce the number of shares that trade on the market. This boosts a company’s earnings per share, which can lead to a higher stock price. But buybacks do not actually improve the business. They just make it look better “on paper.” According to research firm FactSet, 76% of the companies in the S&P 500 bought back their own shares between November and January. Most companies used debt to pay for these buybacks. The Wall Street Journal reported last week: The biggest 1,500 nonfinancial companies in the U.S. increased their net debt by $409 billion in the year to the end of March, according to Société Générale, using almost all—$388 billion—to buy their own shares, net of newly issued stock. Companies have become far and away the biggest customer for their own shares. • Companies are also using “financial engineering” to make their businesses appear healthier… Financial engineering is when companies use accounting tricks to goose their sales, profits, or cash on the balance sheet. It’s how Enron, Valeant, and SunEdison hid problems from investors. Many other companies are doing similar things… As you may know, U.S. corporations are required to report “GAAP” earnings per share. GAAP-based earnings comply with accepted accounting guidelines. A growing number of companies are also reporting “adjusted” earnings that do not comply with GAAP. Many companies use adjusted earnings to strip out “temporary” factors like the strong dollar or a warm winter. Management decides what to leave out and include when measuring adjusted earnings. • Two-thirds of the companies in the Dow Jones Industrial Average report adjusted earnings… In 2014, adjusted earnings were 12% better than GAAP earnings. Last year, they were 31% better. Companies say adjusted earnings give a more complete picture of their business. But it’s becoming obvious that companies are using non-GAAP earnings to hide weaknesses. As Dispatch readers know, the U.S. is in its weakest “recovery” since World War II. Europe, Japan, and China are all growing at their slowest pace in decades too. With the economy so weak, many companies have had to “get creative” to grow earnings. • Sales for companies in the S&P 500 have fallen four straight quarters… Earnings are on track to decline a fourth straight quarter. That hasn’t happened since the 2008-2009 financial crisis. These results would be even uglier if companies didn’t report adjusted earnings. You see, it’s much easier for companies to mask weak sales or profits when the economy is growing. When the economy slows, those problems become too big to hide. Right now, the global economy is clearly slowing. So expect to hear about more “Enrons” in the coming months.center_img Regards, Justin Spittler Delray Beach, Florida May 10, 2016 We want to hear from you. If you have a question or comment, please send it to feedback@caseyresearch.com. We read every email that comes in, and we’ll publish comments, questions, and answers that we think other readers will find useful. • The stock market is a dangerous place to put your money right now… If you’re going to invest in stocks, keep three important things in mind… You should avoid investing in businesses you don’t understand. Many hedge funds wish they had followed this advice with Valeant and SunEdison… Despite these companies’ complex and unclear business models, some of the largest hedge funds in the world invested in them. This earned Valeant and SunEdison the nickname “hedge fund hotels.” We also encourage you to avoid companies with a lot of debt. These firms will struggle to pay the bills as the economy worsens. Finally, we recommend you steer clear of companies that need buybacks to increase earnings. Buybacks can give stocks a temporary boost, but they’re no way to grow a business. In short, money spent on buybacks is money not spent on new machinery, equipment, or anything else that can help a company grow. It’s especially a poor use of cash when stocks are expensive…like they are today. • We encourage you to set aside cash and own physical gold… A cash reserve will help you avoid big losses during the next big selloff. It will also put you in a position to buy world-class businesses for cheap after the “rotten apples” are exposed. Physical gold is another proven way to defend your wealth. Gold has served as real money for centuries because it has a rare set of qualities: It’s durable, transportable, easily divisible, has intrinsic value, and is consistent across the world. It’s also protected wealth through the worst financial crises in history. Investors buy it when they’re nervous about stocks or the economy. This year, gold is up 22%. It’s at its highest level since January 2015. For other proven strategies to protect your money from a stock market crash, watch this short video. In it, you’ll learn how to fully “crisis proof” your wealth. Click here to view this free presentation. Chart of the Day The U.S. stock market is wobbling on one leg… Dispatch readers know buybacks have been a major driver of U.S. stocks. Since 2009, S&P 500 companies have shelled out more than $2 trillion on buybacks. As noted, buybacks can make earnings look better “on paper.” They can also prop up share prices. With the economy slowing and earnings in decline, buybacks have been one of the things keeping stocks afloat…but even that’s starting to give way. Today’s chart compares the performance of PowerShares Buyback Achievers Fund (PKW) this year versus the S&P 500. PKW tracks companies that bought back more than 5% of their shares over the past year. Holdings include McDonald’s (MCD), Lowes (LOWE), and Macy’s (M). From March 2009 to May 2015, PKW gained 314%. The S&P 500 rose 215% over the same period. Since then, PKW has fallen 10%. The S&P 500 is down 3%. Investors appear to be losing confidence in companies that buy a lot of their own stock. That’s a big problem for the stock market, which is showing major signs of weakness. Rickards: “Don’t Buy A Single Ounce Of Gold…” **This is an URGENT warning from Jim Rickards.** If you’ve seen the writing on the wall, like me, you know that gold could soon hit $10,000 per ounce. However, today I’m urging you NOT to buy a single ounce of gold till you read what I have to say. Click here for access to my urgent gold announcement.last_img read more

Study of infrequent cannabis users compares adverse effects of vaping and smoking

first_imgReviewed by Alina Shrourou, B.Sc. (Editor)Dec 4 2018In a small study of infrequent cannabis users, Johns Hopkins Medicine researchers have shown that, compared with smoking cannabis, vaping it increased the rate of short-term anxiety, paranoia, memory loss and distraction when doses were the same.The findings of the new study, described in the Nov. 30 edition of JAMA Network Open, highlight the importance of dose considerations with the perception that vaping is a safer alternative to smoking cannabis, the researchers say. And they ask regulators of medical and recreational cannabis dispensaries to take note.Vaping devices heat cannabis to a temperature in which the mind-altering compounds in the plant are released as a vapor that is inhaled. Vaping is thought to be safer for cannabis and tobacco use because it doesn’t produce many of the harmful components of burning material such as tar and other cancer-causing agents.But, the researchers say, their study suggests that at least for first-timers or others who don’t use cannabis regularly, vaping delivers greater amounts of THC, the primary intoxicant in cannabis, which increases the likelihood of adverse reactions.”In light of increased legalization of cannabis, we designed our study to be more representative of the general population’s exposure to cannabis, namely someone who has never smoked it and wants to try it for medical or recreational purposes, or someone who does not use it regularly enough to understand or predict its effects,” says Ryan Vandrey, Ph.D., associate professor of psychiatry and behavioral sciences at the Johns Hopkins University School of Medicine. “What our study suggests is that some people who use cannabis infrequently need to be careful about how much cannabis they use with a vaporizer, and they should not drive, even within several hours after use. It could be dangerous for themselves and others, and on top of that, they may experience negative effects such as anxiety, nausea, vomiting and even hallucinations,” he adds.For their study, the researchers chose 17 volunteer participants (nine men and eight women, average age 27 years), who hadn’t used cannabis in the past 30 days, which was verified by a drug screen, and together on average hadn’t used in over a year.In a controlled setting at Johns Hopkins Bayview Medical Center’s behavioral pharmacology research unit, each participant either smoked or vaped cannabis containing 0, 10 or 25 milligrams of Δ9-tetrahydrocannabinol (THC), the active component in cannabis that gives people the high, in single visits once a week over six weeks. The researchers say that 25 milligrams of THC is a relatively low dose, and much less than is typically found in pre-rolled cannabis “joints” sold in dispensaries where cannabis is legal. The participants either smoked preloaded pipes or inhaled vapor from a vaporizer. Neither the participants nor the researchers knew the doses of THC that were delivered in a given experimental test session.During each of the six sessions, the research team observed and assessed drug effects in the test subjects, including for adverse reactions. They also measured vital signs such as heart rate and blood pressure and collected blood samples just after smoking, every 30 minutes for two hours and then every hour for eight hours.Each participant also completed the Drug Effect Questionnaire–rating self-reported drug effects out of a score of 100–shortly after smoking and each hour for up to eight hours later. The survey assessed overall drug effect; feeling sick, anxious, hungry, sleepy and restless; and experiencing heart racing, dry mouth, dry eyes, memory impairment and coughing.Results showed that a few minutes after smoking, those who vaped the 25-milligram THC dosage reported an average of 77.5 on the overall strength of the drug’s effect, meaning how high they felt compared with the average score of 66.4 reported by those who smoked the same dose. Participants who vaped 25 milligrams of THC reported about a 7 percent higher score on average for anxiety and paranoia, compared with people who smoked the same amount of the compound. Those who vaped any dose of THC also reported higher levels of dry mouth and dry eyes than those who smoked it. For example, when vaping 25 milligrams of THC, the participants rated dry mouth at 67.1 on average compared with 42.6 for those smoking it.Related StoriesNew study shows clear link between cannabis use and brain alterationsStudy: Less than 50% of U.S. adults exposed to court-ordered anti-smoking advertisementsCannabis use during pregnancy may cause premature birthResearchers say the participants also completed three computerized tasks designed to measure attention span, memory, physical reaction time and motor movement. One task required the participant to replicate the shape of patterns, another required them to add up strings of single-digit numbers and the third required them to follow a dot across the screen with the cursor while also tracking a dot that pops up in the periphery.The tests are meant to represent skills needed for proper workplace performance, operating a car or other daily activities. Reaction times on average were slower by more than 120 milliseconds with both active test doses of THC, using either smoking or vaping, when compared with reaction time after smoking or vaping cannabis without any THC.Next, the researchers compared the effects of vaping compared with smoking on participants taking the computerized Divided Attention Task, which required participants to track a square on the computer screen while also monitoring numbers in each corner of the screen. The amount of time participants accurately tracked the square on the computer in the Divided Attention Task dropped by an average of 170 percent after smoking 25 milligrams of THC compared with the cannabis without THC.The amount of time they accurately tracked fell an average of 350 percent when vaping 10 milligrams of THC and fell 500 percent when vaping 25 milligrams of THC, compared with those smoking either dose.”Our participants had substantially higher impairment on the tasks when vaping versus smoking the same dose, which in the real world translates to more functional impairment when driving or performing everyday tasks,” says postdoctoral fellow Tory Spindle, Ph.D., a researcher in the behavioral pharmacology research unit at Johns Hopkins Bayview.Other results showed that blood levels of THC were at their highest immediately after smoking or vaping cannabis. At 10 milligrams of THC, blood levels of THC reached an average of 7.5 nanograms per milliliter in vapers, compared with 3.8 nanograms per milliliter in smokers 10 minutes after they inhaled the drug. At 25 milligrams of THC, blood levels reached an average of 14.4 nanograms per milliliter when vaped compared with 10.2 nanograms per milliliter when smoked.”There’s a definite differences in the amount of drug making it into the blood when using a vaporizer versus smoking the drug, so considerations need to be made when dosing to ensure people are using cannabis safely,” says Spindle.The researchers note that they could only detect THC in the blood samples up to four hours after using, even though the participants reported the drug’s effects lasted five or six hours. The researchers say this suggests that blood testing isn’t an accurate way to tell if someone is high or perhaps driving under the influence.Two participants vomited after vaping 25 milligrams of THC, and another experienced hallucinations. One person vomited after smoking 25 milligrams of THC.Vandrey cautions that the study involved only a small number of younger adults and lasted only six weeks. “We still don’t have a full look at the long-term effects of vaping, such as whether there is a risk for chronic bronchitis, and more work needs to be done on that front,” he says. It is important to note that these effects were observed in individuals who don’t use cannabis very often, and may not extend to people who use cannabis routinely; they may have developed tolerance to these effects and also may be better able to regulate their dose.In recent years, Canada and several U.S. states including Washington, California, Colorado and Massachusetts have legalized cannabis for recreational use. Thirty-two states have made cannabis available with a doctor’s prescription, including Maryland, where the research was performed.Source: https://www.hopkinsmedicine.org/news/newsroom/news-releases/vaping-cannabis-produces-stronger-effects-than-smoking-cannabis-for-infrequent-userslast_img read more

Researchers find more effective way to treat drugresistant cancers

first_imgMuch of the research led by CD4 director Pia Vogel and Wise is centered on a class of proteins called ABC transporters, a key factor in why many cancers resist chemotherapy.”These transporters are defensive proteins and are normally very, very good for us. They protect us from toxic chemicals by literally pumping them out of the cell, almost like a sump pump removes water from one’s cellar,” Vogel said.But when someone has cancer, these proteins do more harm than good.”One protein, P-glycoprotein, can pump nearly all chemotherapeutics out of the cancer cell, thereby making the cancer resistant to many drugs and untreatable,” Wise noted.For this reason, SMU researchers tested the combination of using an inhibitor that temporarily shuts down P-glycoprotein’s ability to remove drugs from the cancer cells along with chemotherapeutics on prostate cancer cells grown in the lab, which have been shown to be resistant to multiple chemotherapeutic drugs.Related StoriesLiving with advanced breast cancerVirus killing protein could be the real antiviral hero finds studyNew study to ease plight of patients with advanced cancerThe SMU team was able to show that if inhibitors of P-glycoprotein are used during and after the multidrug resistant cancer cells have been exposed to the chemotherapy drugs, then the cancer cells become much more sensitive to the chemotherapeutics.The recipe for success was giving cancer cells a dose of both chemotherapy drugs and the P-gp inhibitor for just two hours. Researchers then washed the prostate cancer cells to get rid of any residual chemotherapy drugs before giving the cells another dose of just P-gp inhibitor for 22 hours, lead author and SMU Ph.D. doctoral candidate Amila K. Nanayakkara explained.Prostate cancer cells that were given this treatment were shown to retain chemotherapy drugs at a much higher level compared to cancer cells not treated with the P-glycoprotein inhibitor. After about 24 hours, much fewer of these cancer cells survived in this treatment compared to the cells which had not seen the inhibitor.When the same tests were performed on normal noncancerous cells, “there was no sign of extra toxicity to the healthy cells using this method,” Wise added.One issue, though, is how to duplicate this method in a patient’s body. “Once you’ve taken a chemotherapy drug, it’s not easy to remove it after just two hours,” said co-author Vogel, a professor in the SMU Department of Biological Sciences.Still, the researchers argued that it is worth further research, because there are currently few options for cancer patients once their disease becomes resistant to multiple chemotherapies.”Our paper shows these remarkable effects when the inhibitor is present during, and importantly, after exposure to chemotherapeutic,” Wise said. “And while ‘washing’ is not feasible in humans, the kidneys and other organs are in a sense doing the washing step for a patient. These organs are washing the chemotherapy from the bloodstream and therefore, out of cancer cells. So in that way, we think our preliminary cell culture studies may be translatable at least in principle to animals and people.” Reviewed by James Ives, M.Psych. (Editor)Jun 10 2019Researchers at SMU’s Center for Drug Discovery, Design and Delivery (CD4) have succeeded in lab testing the use of chemotherapy with a specific protein inhibitor so that the chemotherapeutic is better absorbed by drug-resistant cancer cells without harming healthy cells. The approach could pave the way for a more effective way to treat cancers that are resistant to treatment.A mix of drugs is frequently used to shrink cancer tumors or keep tumor cells from spreading to other parts of the body. But chemotherapy is so toxic that the mix often kills healthy cells, too, causing dreadful side effects for cancer patients. And eventually, many cancers learn how to resist chemotherapy, making it less effective over time. When multidrug resistance evolves, this leaves the patient with a very poor prognosis for survival and the oncologist with few, if any, effective tools, such as chemotherapy medicines, to treat what is very likely an aggressive and/or metastatic cancer at this point.”John Wise, associate professor in the SMU Department of Biological Sciences and co-author of a study on the findings published in PLOS ONEcenter_img Source:Southern Methodist Universitylast_img read more

Floods affect 1991 million people

first_img Philippines 9h ago UN to look into Philippines deaths in war on drugs Related News {{category}} {{time}} {{title}} BEIJING: A total of 19.91 million people have been affected by floods since the beginning of the flood season this summer in China, according to the Ministry of Emergency Management. Related News Tags / Keywords:center_img Philippines 9h ago Philippine hit over ‘secret talks’ with fishermen The country had relocated about 1.3 million people due to floods, while 582,000 people were in need of emergency aid, the ministry said.The ministry has pledged to make every effort to meet the basic living needs of those stricken by floods. It will also work with water resource departments to intensify the patrol and maintenance of major dams and embankments, deploy more rescue forces in heavily flooded areas and make contingency plans for serious disasters. — China Daily/Asia News Network China 9h ago Four Britons held in China Chinalast_img read more