8 days agoBarca coach Valverde confirms Messi close to full fitness

first_imgAbout the authorCarlos VolcanoShare the loveHave your say Barca coach Valverde confirms Messi close to full fitnessby Carlos Volcano8 days agoSend to a friendShare the loveBarcelona travel to Eibar with Lionel Messi moving towards full fitness.Barca coach Ernesto Valverde confirmed Messi was close to a return to being 100 per cent after an injury-ravaged start to the campaign.He said, “He is in the process of being 100 percent fit.”The other day he played 90 minutes and scored, that always reassures the strikers,” he told the press.”He has to go slowly to find reach top form. He only has one full game under his belt.”We hope he can give us much more in the coming matches.” last_img read more

CANADIAN PERFORMERS RATIFY TERMS OF NEW NATIONAL COMMERCIAL AGREEMENT

first_img Login/Register With: Advertisement Advertisement Advertisement TORONTO, ON (August 4, 2017) — ACTRA Members have voted (78 per cent) in favour of ratifying the 2017-2020 National Commercial Agreement (NCA).The 2017-2020 NCA settlement provides for a new single Digital Media Use fee payable on all commercials produced for or moved over to Digital Media. The Agreement also promotes new work opportunities for performers in low-budget digital media commercials with the ACTRAonline Opportunity Pilot Project. All rates and fees in the Agreement with the exception of the Pilot Project will increase by 6 per cent over three years commencing with a 2 per cent increase effective August 5, 2017. The settlement represents an estimated increase of $3M in performers’ compensation over the 3-year term of the new Agreement, which generated over $45M in performer earnings in 2016.“In these changing and challenging times in the advertising industry, we have achieved a settlement that creates new work opportunities and provides substantial improvements for ACTRA performers,” says David Sparrow, ACTRA National President and Negotiating Committee Chair. “I’m incredibly proud of the ACTRA members who served on our bargaining team and all the members who helped make this new deal a reality.” Twitter LEAVE A REPLY Cancel replyLog in to leave a comment “Unions around the world are facing employer demands for rollbacks at the bargaining table. Global competition for commercial production is more intense now than ever. In this climate, ACTRA members have achieved an Agreement that makes it easier than ever to hire the most talented performers in Canada and ensures performers are fairly compensated their work,” added Stephen Waddell, Chief Negotiator and National Executive Director.The Alliance of Canadian Cinema, Television and Radio Artists (ACTRA), the Association of Canadian Advertisers (ACA) and the Institute of Communication Agencies (ICA) commenced negotiations in Toronto on June 7, 2017. The NCA covers the engagement of Performers in all television, radio and digital commercial production in Canada. Voting commenced on July 19, 2017, and closed today on August 4. The new agreement will take effect August 5, 2017, and will expire on June 30, 2020.ACTRA (Alliance of Canadian Cinema, Television and Radio Artists) is the national union of professional performers working in the English-language recorded media in Canada. ACTRA represents the interests of 23,000 members across the country – the foundation of Canada’s highly-acclaimed professional performing community. Facebooklast_img read more

New drug compounds show promise in treating acute myeloid leukemia

first_imgReviewed by James Ives, M.Psych. (Editor)Jan 29 2019Researchers have been struggling for years to find a treatment for patients who have a recurrence of acute myeloid leukemia (AML), an aggressive blood cancer that is one of the most lethal cancers. About 19,520 news cases are diagnosed a year, and about 10,670 people a year die from it, according to the American Cancer Society.Purdue University researchers are developing a series of drug compounds that have shown promise in treating such cases. About 30 percent of AML patients have a mutation caused by a kinase called FLT3, which makes the leukemia more aggressive. Inhibitors of FLT3, such as Radapt, approved last year by the U.S. Food and Drug Administration, have shown good initial response to treating leukemia. Gilteritinib, another FLT3 inhibitor, was recently approved toward the end of 2018. But AML patients on FLT3 inhibitor therapy often relapse because of secondary mutations in the FLT3 and existing treatments have not been fully successful in treating those cases.Researchers on a team led by Herman O. Sintim, the Drug Discovery Professor of Chemistry in Purdue’s Department of Chemistry, say they have developed a series of compounds that work not only on AML with common FLT3 mutation, but also drug-resistant AML harboring problematic mutations, such as the gatekeeper F691L mutation, which some leukemia patients who relapse harbor.”These compounds have a great potential to be the next-generation AML therapeutics for relapsed patients who no longer respond to first- or second-generation FLT3 inhibitors,” Sintim said.The results of the study were published Friday here in the journal EBioMedicine.The research aligns with Purdue’s Giant Leaps celebration, recognizing the university’s global advancements made in health, longevity and quality of life as part of Purdue’s 150th anniversary. This is one of the four themes of the yearlong celebration’s Ideas Festival, designed to showcase Purdue as an intellectual center solving real-world issues.Results of the study are encouraging because, while advancements have been made in many other forms of cancer over the past three decades, advancement for AML has been slow.AML, which accounts for only about 1 percent of all cancers, occurs when blood cells fail to mature or differentiate and multiply unchecked, causing a lack of adequate oxygen-carrying red blood cells. AML is uncommon before the age of 45, but it does occur in children. The five-year survival rate is about 30 percent, and for patients over the age of 65, the five-year survival rate is less than 10 percent.Related StoriesStudy shows how SIRT1 plays key role in maintaining the regenerative potential of leukemic stem cellsImmune-boosting compound could make pancreatic cancers susceptible to immunotherapyResearchers discover biochemical agent responsible for blood pressure drop in sepsisThe compounds the Purdue researchers are studying, alkynyl aminoisoquinoline and alkynyl napthyridine, have been successful in preclinical studies, Sintim said. “In mouse studies, almost no leukemia burden was visible after compound treatment for only a few weeks. Crucially this new class of FLT3 inhibitor also works against drug-resistant secondary mutations, such as the problematic F691L mutatio,” Sintim said.In the clinic, the goal is to reduce leukemia levels enough so that a patient can undergo a bone marrow transplant. Most often if the leukemia burden is not drastically reduced before bone marrow transplant, there is a high likelihood that the AML will return.Sintim said the compounds the researchers are developing have shown no signs of toxicity. Observations in clinical testing show that high doses of the compounds result in no weight loss, irritability or essential organs dysfunction. Another advantage of the compounds the Purdue researchers are developing is they can be taken orally, which makes it easier for patients to take at home compared with an injection.Sintim said there’s much still to be learned about AML.”Acute myeloid leukemia is not caused by only one mutation. It’s caused by many mutations. What that means is that you might have an acute myeloid leukemia patient who would have one type of a mutation and you could have another one with another type of mutation and you cannot give them the same drug. Even when a patient initially presents with one type of mutation, during treatment a new mutation could emerge” he said. “So to effectively treat a cancer you need to know what the aligning mutation is, this is what is called precision medicine; tailoring a drug to a particular disease driver.”Sintim also is a co-founder of a biotech startup called KinaRx LLC, which has licensed the compounds the researchers are working on through Purdue’s Office ofTechnology Commercialization. Both Sintim’s lab and KinaRx LLC are looking for development partners. Source:https://www.purdue.edu/newsroom/releases/2019/Q1/drug-compound-could-be-next-generation-treatment-for-aggressive-form-of-leukemia.htmllast_img read more

Twitter seeks help measuring health of its world

Twitter is asking for outside experts to assess the health of its platform by measuring the impact of abuse and manipulation Twitter on Thursday asked for outside help assessing the health of its world of rapid-fire commentary in the hope of finding cures for trolls, bots, echo chambers and other ills. © 2018 AFP This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Pressure has been building on Twitter—as well as Facebook and Google—to prevent malicious uses of the online platform ranging from harassment to spreading hoaxes and manipulating elections.”We have witnessed abuse, harassment, troll armies, manipulation through bots and human-coordination, misinformation campaigns, and increasingly divisive echo chambers,” Twitter co-founder and chief executive Jack Dorsey said in a thread of tweets Thursday.”We aren’t proud of how people have taken advantage of our service, or our inability to address it fast enough.”A Twitter statement said the social network wants “to partner with outside experts” to get a sense of the health of the Twittersphere by measuring the impact of abuse, spam and manipulation.The move is the latest by Twitter aimed at curbing disinformation, propaganda and provocation.Last month, the San Francisco-based one-to-many messaging service launched a crackdown on accounts powered by software “bots” which can artificially amplify a person or cause and which have been accused of manipulating the social network during the 2016 US election.Twitter said the move was intended to rid the service of spam-spewing automated accounts, and not aimed at people using the service according to the rules.Since the election, Twitter and others discovered how “bots” had been used to sow political divisions and spread hoaxes.While Twitter tactics have mostly involved removing content violating its terms of use, it has been accused of “apathy, censorship, political bias, and optimizing for our business and share price instead of the concerns of society,” Dorsey maintained.”This is not who we are, or who we ever want to be,” he said.Twitter is asking outside experts to pitch proposals for ways to measure the service’s health by the quality of debates, conversations, and critical thinking.”We simply can’t and don’t want to do this alone,” Dorsey said.Twitter asked proposals to be submitted by April 13, promising to fund any that are selected in a process expected to take a couple of months.”If you want to improve something, you have to be able to measure it,” Dorsey said. Citation: Twitter seeks help measuring ‘health’ of its world (2018, March 1) retrieved 18 July 2019 from https://phys.org/news/2018-03-twitter-health-world.html Twitter sets crackdown on automated ‘bot’ accounts Explore further read more

Edward C Baig Have a great idea for 5G Verizon may give

first_imgAccording to Shamunder, “There should be potential for it to be monetizable, but every idea doesn’t have to be like that. It can be something that can be used to solve some unique societal problem as well.”Verizon claims it is motivated by the concept of generating such ideas and not because of any of the extra marketing attention the challenge brings to its 5G as it launches these networks at the same time that rivals such as AT&T, T-Mobile and Sprint do.Shamunder concedes that the marketing aspect is a “byproduct,” but hardly the main purpose.”We don’t have a monopoly on ideas,” she says. “There are people out there who have deep insight into certain industries and that have their own unique problems. We have these toolboxes we want them to use to solve these problems and they are better at doing that than I am.”The various legal and other requirements that are part of the challenge are still being hammered out and will be posted on a Verizon website; it is probably safe to assume that Verizon will retain first right of refusal over any idea that is selected.It is unclear what kind of ownership stake Verizon will take in any of the winning ideas.This isn’t, in fact, the first time Verizon has challenged outsiders to develop ideas for 5G. In partnership with Ericsson and the Mass Tech Leadership Council, Verizon in November announced the launch of the Verizon 5G Robotics Challenge for universities, startups, and other developers in the greater Boston area to create 5G-powered robotics technologies that will transform modern industry. The pool money in that challenge was $300,000. Winners have not yet been selected. It has issued another similar challenge geared toward first responders.Verizon describes its far broader latest challenge as “a nationwide search for the biggest and brightest ideas that will bring the true power of 5G to life. Winners will be judged on innovation, commercial viability, and the potential impact and sustainability of how their ideas will be able to make the world a better, more connected place.”Judging will begin in the spring. Explore further Think you’ve come up with a killer idea for exploiting the emerging next-generation wireless networks known as 5G? (c)2019 USA TodayDistributed by Tribune Content Agency, LLC. Verizon cuts 10,000 workers through buyouts as part of restructuringcenter_img This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. If Verizon buys into in your vision and considers it commercially viable, the company will issue you up to a cool $1 million in seed money. What’s more, you’ll be invited to develop the concept on live networks in one of Verizon’s 5G incubator labs, in New York City; Cambridge, Massachusetts; Los Angeles; Palo Alto, California, and Washington, D.C. And Verizon will provide training and technical support to the chosen innovators.It’s all part of a “Built on 5G Challenge” launched this week at CES in Las Vegas during a keynote address by Verizon CEO Hans Vestberg.5G is all about blistering speeds and low latency or network responsiveness, but the promise behind the technology extends well beyond the wicked fast handset you hope to carry in your pocket. There’s surely no small amount of hype around 5G, with Verizon referring to it as the “fourth industrial revolution.” The tech is meant to play an important role in self-driving cars, remote medicine, immersive education and all things connected, whether in your home, business or entire “smart community.”How might you play a small part in the revolution? Verizon’s challenge is open to venture-funded companies, bootstrapped startups, non-profits, educators, and yes, creative individuals. The $1 million that the company promises to dish out represents a pool of money that will be shared among a limited selection of potential winners; no more than two or three seems likely. If you’re the only one you could get the full million.Not just a PowerPointApplicants must meet certain criteria, says Sanyogita Shamunder, a network vice president for 5G ecosystems and innovation at Verizon. Is what you’ve cooked up real? What capabilities does the idea use? Can it realistically be implemented, given the current state of artificial intelligence, available hardware or other technologies? And does it really require 5G?”It can’t be just a PowerPoint. There needs to be a proof of concept,” Shamunder says.It’s too soon to tell, she adds, whether chosen ideas will turn into actual commercial products. Verizon could acquire the winning company behind an innovative idea—or not. It could license some aspect of the technology—or not. Citation: Edward C. Baig: Have a great idea for 5G? Verizon may give you a million dollars to make it happen (2019, January 16) retrieved 17 July 2019 from https://phys.org/news/2019-01-edward-baig-great-idea-5g.htmllast_img read more

5 Strange Cool Things Weve Recently Learned About the Moon

first_img Originally published on Live Science.by Taboolaby TaboolaSponsored LinksSponsored LinksPromoted LinksPromoted LinksYou May LikeVikings: Free Online GamePlay this for 1 min and see why everyone is addicted!Vikings: Free Online GameUndoTruthFinder People Search SubscriptionOne Thing All Liars Have in Common, Brace YourselfTruthFinder People Search SubscriptionUndoTop 10 Best Meal DeliveryMeal Kit Wars: 10 Tested & Ranked. See Who WonTop 10 Best Meal DeliveryUndoFinance101What Are The Best States To Retire In?Finance101UndoBirch Gold GroupThis IRS Tax Law is Sweeping the U.S.Birch Gold GroupUndoAnti-Snoring SolutionA Simple Fix for Snoring And Sleep ApneaAnti-Snoring SolutionUndo 5. The moon is two-faced (probably because of a massive asteroid). Ours is a moon with two faces: the nearside boasts a thinner and smoother crust, while the farside crust is thicker and dotted by impact craters left nearly undisturbed by lava flows. The discrepancies have vexed scientists for decades, and in a new paper, researchers use models to explore what may be possible explanations for the stark differences. They argue that those distinctive sides could be the result of a giant impactor slamming into the moon and leaving a massive crater across the entire nearside. [Read more about what created the moon’s two faces.] Discover more fascinating facts about the moon with BBC America’s “Wonders of the Moon,” premiering Friday, July 19 at 10 p.m. EDT/9 p.m. CDT. 3. The moon is shrinking and quaking. The moon is shrinking. And as the crust of our lone satellite contracts, it tugs on cliff-like cracks on the surface, leading to lots of moonquakes, researchers have discovered. Scientists revisited moonquake data gathered from 1969 to 1977 by seismic equipment on the Apollo lunar missions. They mapped the seismic data to satellite images of thrust faults, or scarps — stairstep cliffs on the lunar surface. These formations stand dozens of feet high and extend for miles, and they are visible in images captured by NASA’s Lunar Reconnaissance Orbiter. The researchers discovered that around 25% of the moonquakes were likely generated by released energy from these faults, rather than by asteroid impacts or activity deep inside the moon. Scarps are spread across the face of the moon in a vast, global network, and are estimated to be no more than 50 million years old, the researchers wrote. The age and distribution of the scarps hint that they appeared as the moon’s interior cooled down, causing its crust to contract. [Read more about the moonquakes] A stunning shot of the 2017 total solar eclipse as soon from the Armstrong Flight Research Center at Edwards Air Force Base in California. Credit: Carla Thomas/NASA/BBC America A burnt-orange moon hangs over London. Although scientists have unraveled many of the moon’s mysteries in the 50 years since Apollo 11, mankind’s enchantment with our nearest neighbor has never dimmed. Credit: James Burns/BBC America The International Space Station’s incredible view of the moon. Credit: Luca Parmitano/BBC America 2. There’s an enormous, dense blob of metal below the surface of the moon’s south pole. Deep below the moon’s South Pole-Aitken basin (the largest preserved impact crater anywhere in the solar system), researchers have detected a gargantuan “anomaly” of heavy metal lodged in the mantle that is apparently altering the moon’s gravitational field. According to a study of the mysterious blob, published April 5 in the journal Geophysical Research Letters, the anomaly likely weighs somewhere in the neighborhood of 2.4 quadrillion tons (2.18 quintillion kilograms). The researchers aren’t sure how this giant blob of metal got itself trapped below the lunar surface. Simulations suggest it could be the heavy remnants of the iron-nickel asteroid that crashed into the far side of the moon and created the giant South Pole-Aitken crater some 4 billion years ago. [Read more about the massive blob beneath the moon.] Gallery: The Fantastic Full Mooncenter_img See Spectacular Lunar Mission Images in 3D (Photos) A beautiful bright moon illuminates Brecon Beacons National Park in Wales, UK. Credit: Allyn Wallace/BBC America 1. There is water on the moon, and it jumps around. In 2009, data from NASA’s Lunar Reconnaissance Orbiter (LRO) led to the discovery of water on the moon locked up in ice. A recent upgrade to the orbiter, called the Lyman Alpha Mapping Project (LAMP), has allowed scientists to take a closer look at the water on the lunar surface. LAMP has revealed that water molecules move around the moon as the lunar surface warms and cools throughout the day. Water remains stuck on the moon’s surface until the lunar midday, when some of the water melts and heats up enough to lift into the moon’s delicate atmosphere. The water floats around a bit until it reaches an area cool enough to make it settle back down to the surface.Advertisement Water on other planetary bodies could be a valuable resource for human explorers to not only drink but also to serve as fuel for future robotic exploration, since water can be split to form rocket fuel, saving missions from having to carry that fuel from Earth. [Read more about how water hops around the moon.] Find Apollo 11 Landing Site While Skywatching The MoonFor the 50th anniversary of humanity’s first steps on the lunar surface, learn 5 facts about our moon and where to find the Apollo 11 landing site while viewing it in the night sky. Credit: NASA/JPL-CaltechVolume 0%Press shift question mark to access a list of keyboard shortcutsKeyboard Shortcutsplay/pauseincrease volumedecrease volumeseek forwardsseek backwardstoggle captionstoggle fullscreenmute/unmuteseek to %SPACE↑↓→←cfm0-9接下来播放Better Bug Sprays?01:33关闭选项Automated Captions – en-US facebook twitter 发邮件 reddit 链接https://www.livescience.com/65943-strange-facts-about-the-moon.html?jwsource=cl已复制直播00:0003:1903:19Your Recommended Playlist01:33Better Bug Sprays?04:24Sperm Whale Befriends Underwater Robot01:08Why Do French Fries Taste So Bad When They’re Cold?00:29Robot Jumps Like a Grasshopper, Rolls Like a Ball02:31Surgical Robotics00:29Video – Giggly Robot关闭  Photos: Mysterious Objects on the Moon It’s been almost 50 years since a human first set foot on the moon. Since then, our knowledge about Earth’s closest neighbor has improved by leaps and bounds, and our obsession with it has never waned. Witness some of the most amazing images of the moon ever recorded and be reminded of the significant influence of our moon in BBC America’s new documentary “Wonders of the Moon,” premiering Friday, July 19 at 10 p.m. EDT/9 p.m. CDT. As the world begins its commemoration of the awe-inspiring first walk on the lunar surface, let’s review five of the most recent and fascinating scientific findings about the moon. 4. You won’t strike it rich on the moon. Gold, platinum and other metals known as highly siderophile (“iron-loving”) elements are far more abundant in Earth’s crust than they are in its natural satellite. That may seem odd, given the two worlds’ shared history. About 4.5 billion years ago, a Mars-size planet dubbed Theia slammed into the proto-Earth, blasting huge amounts of material from both bodies into space. Some of this liberated stuff was incorporated into the bruised and battered Earth, and some coalesced to form the moon. But highly siderophile elements (HSEs) appear to have been left out of the mix. These metals were likely delivered by later asteroid strikes — but why does Earth have so much more than the moon? The researchers suspect that the moon’s weaker gravitational pull means material delivered via impact isn’t as likely to have stayed on the moon as it did on Earth — lots of stuff that hits the moon returns to space. The small concentration of HSEs retained on the moon likely arrived before the moon’s magma ocean cooled and solidified, so the material became incorporated into the moon’s core. [Read more about why Earth has way more gold than the moon.]last_img read more

Amit Shah files nomination for Gandhinagar LS seat

first_imgnational elections SHARE SHARE EMAIL RELATED Gandhinagar March 30, 2019 BJP President Shri Amit Shah waves to people during a Road Show in Ahmedabad on Saturday, March 30, 2019   –  The Hindu Gujarat Published on COMMENT SHARE There were issues between Sena and BJP, but resolved now: Uddhav Thackeray BJP veteran and former deputy Prime Minister L K Advani had won for five consecutive terms from this constituency (1998 to 2014). The 91-year old leader, however, has not been given a ticket this time. After a mega show-of strength on Saturday in Ahmedabad, Bhartiya Janata Party (BJP) president Amit Shah filed his nomination papers for the Gandhinagar Parliamentary constituency eyeing a debut to the Lok Sabha from the saffron bastion.Shah handed over his nomination papers to the Gandhinagar district collector in presence of Union Home Minister Rajnath Singh, Finance Minsiter Arun Jaitley and Thackrey.The seat is currently represented by BJP veteran and former deputy Prime Minister Lal Krishna Advani, who had won for five consecutive terms from 1998 to 2014. The 91-year old leader, however, has not been given a ticket this time. The opposition party, Congress has yet not declared its candidate for Gandhinagar constituency. Top brass of the Central BJP leadership and the key National Democratic Alliance (NDA) allies such as Uddhav Thackrey from Shiv Sena, Ram Vilas Paswan from Lok Janshakti Party and Prakash Singh Badal from Shiromani Akali Dal remained present at the rally.TributesBefore heading to Gandhinagar later in the day, Shah paid tributes to Sardar Vallabhbhai Patel’s statue in Ahmedabad and addressed a large gathering of BJP supporters on Saturday morning. “The party has nominated me from Gandhinagar constituency, which has been represented by Advaniji for long. He worked hard to make this constituency among the most developed ones. I will try to continue his legacy forward,” said Shah, who is currently a Rajya Sabha MP from Gujarat. Notably, before being nominated for Rajya Sabha, Shah had represented a large portion of the Gandhinagar LS constituency in the State Assembly as an MLA from earlier Sarkhej and then Naranpura Assembly constituencies.Eyeing a debut to the Lower House of the Parliament, Shah recalled his journey within the party, “There will be nothing left for me, if BJP is taken away from my life. Whatever I have learnt and catered to the nation, it all belongs to the BJP.”SupportEarlier, Ram Vilas Paswan and Uddhav Thackrey made public address raising questions on the united opposition front under Mahagathbandhan and the Congress. “They have in-fighting about their leader. How can they give a stable government to the country? We will not be among those who back-stab (the BJP). On the principles laid down by My father, our party will support Prime Minister Narendra Modi for the next term,” said Thackrey amid clamour in support of “Modi Again”.Other senior BJP leaders present at the rally were Union Transport Minister Nitin Gadkari and Railways Minister Piyush Goyal besides the Chief Minister of Gujarat Vijay Rupani and deputy Chief Minister Nitin Patel along with State party chief Jitu Vaghani. The Gandhinagar constituency, having an electorate of about 19.20 lakh voters, will go to polls in the third phase on April 13. BJP COMMENTSlast_img read more